Bioavailability of cannabis suppositories.
Rectal administration allows avoidance of these effects and furthermore, a greater proportion of CBD is allowed to eventually reach the blood stream. This form for administration offers a much faster uptake than oral administration (approximately 10 minutes, on average). The speed and reliability of their uptake combined with their circumvention of many issues surrounding both ingestion and inhalation make rectal applications an excellent addition to both new and pre-existing therapeutic regimens.
With suppositories, initial effects will most often be noticed within 10-15 minutes after application, and these effects will usually last 4-8 hours depending on the physiology and tolerance for cannabis of the individual.
However, there are several issues that can slow absorption from the rectum to the blood stream. Diarrhea, fecal matter and tumors or cysts on the rectum wall can slow or prevent the cannabinoids from reaching the rectal wall and being absorbed. Rectal dehydration can also drastically reduce the effectiveness of suppositories. Staying well hydrated by maintaining a healthy consumption of both water and electrolytes may prevent this. However, specific medical condition may also cause rectal dehydration, in which case the solution may not be as simple. In case of concern, medical professionals should be consulted.
Suppositories can be used to refine existing therapeutic regimens to greater effects. People, who have been prevented from using cannabis due to inability to administer via ingestion or inhalation, can potentially derive benefit from cannabis for the first time by using cannabis suppositories.
Directions: For rectal use or as vaginal capsule. Refrigerate before using. Use good hygiene and wash hands before and after use. To remove suppository, tear the plastic shell lengthwise beginning at the “V” shaped cut at the pointed end of the suppository. Apply a light coating of water lubricant to the suppository before insertion. FOR RECTAL INSERTION: insert suppository past sphincter muscle. Try to wait 15 to 20 minutes before another bowel movement. Broken suppositories may be reheated in the shells in a sealable waterproof bag in warm water until melted and then reformed in a refrigerator. Occasional air bubbles in suppository are normal and do not indicate a loss of product. FOR VAGINAL INSERTION: Capsule to be inserted high in the vagina. This is best done in a reclining position.
Suppositories should be stored in the fridge (at 2°C to 8°C).